CEACAM3

Carcinoembryonic antigen-related cell adhesion molecule 3 (CEACAM3) also known as CD66d (Cluster of Differentiation 66d), is a member of the carcinoembryonic antigen (CEA) gene family..[3]

CEACAM3
Identifiers
Aliases CEACAM3, CD66D, CEA, CGM1, W264, W282, carcinoembryonic antigen related cell adhesion molecule 3, CEA cell adhesion molecule 3
External IDs OMIM: 609142HomoloGene: 130497GeneCards: CEACAM3
Gene location (Human)
Chr. Chromosome 19 (human)[1]

Band 19q13.2 Start 41,796,587 bp[1]
End 41,811,554 bp[1]
RNA expression pattern
Bgee
Top expressed in
  • blood
  • bone marrow
  • vastus lateralis muscle
  • spleen
  • periodontal fiber
  • appendix
  • islet of Langerhans
More reference expression data
BioGPS

More reference expression data
Orthologs
Species Human Mouse
Entrez

1084

n/a

Ensembl

ENSG00000170956

n/a

UniProt

P40198

n/a

RefSeq (mRNA)

NM_001277163
NM_001815

n/a

RefSeq (protein)

NP_001264092
NP_001806

n/a

Location (UCSC) Chr 19: 41.8 – 41.81 Mb n/a
PubMed search [2] n/a
Wikidata
View/Edit Human

This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[3]

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CEACAM3 is expressed exclusively on granulocytes and used as granulocyte marker.[4]

  1. GRCh38: Ensembl release 89: ENSG00000170956Ensembl, May 2017
  2. “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. “Entrez Gene: CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3”.
  4. CEACAM3: an innate immune receptor directed against human-restricted bacterial pathogens. Pils S, Gerrard DT, Meyer A, Hauck CR. Int J Med Microbiol. 2008 Oct;298(7-8):553-60.

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